Delay of COX-2 of optional choose sex gets together the agent is a kind of new-style NSAIDs, yinjike checks optionally COX-2 particularity, lesser to COX-1 influence, show level general in order to kind of rheumatism and osteoarthritis fight infection, acetanilide cure.
Delay of COX2 of optional choose sex gets together agent one, the introduction
The body that be not steriod fights phlogistic drug (NSAIDs) it is cure the familiar drug of urgent chronic ache, its combat infection, acetanilide, antife武汉夜网论坛brile effect is the basis checks annulus oxidation is enzymatic (COX) finish. COX includes东莞夜品茶网 2 kinds to be the same as labour enzymatic isomer, namely COX-1 and COX-2. COX-1 is a kind of original guard the entrance enzymatic, its key is put have in function of stomach, kidney and plaque, the prostate element E2 that catalytic reaction creates physiological need (PGE2)佛山夜品茶网 , obstruction of attrition of blood-vessel of the we武汉夜网论坛ek outside adjusting, hold kidney blood size, safeguard gastric mucous membrane to reach adjust plaque to gather. COX-2 is suffer in airframe send after phlogistic element is excitant, what wait to be stated quickly by cell of odd core huge bite, fiber cell is enzymatic, be called revulsive enzymatic, be those who create phlogistic sex sense is important enzymatic one of, can drive phlogistic sex appeal to become aware, cause an organization to damage. Of traditional pattern NSAIDs acetanilide, combatting infection effect is to check the Jian fruit of COX-2. Delay of COX-2 of optional choose sex gets together the agent is a kind of new-style NSAIDs, yinjike checks optionally COX-2 particularity, lesser to COX-1 influence, side-effect is compared lesser light, show level general in order to kind of rheumatism and osteoarthritis fight infection, acetanilide cure.
Delay of COX2 of optional choose sex gets together agent 2, action mechanism
COX-2 delay gets together agent (Coxib) group of a few working can be inserted into by COX-2 one part amino acid incomplete base the scanty water antrum of generation, make its generation changes compose loses catalytic reaction action, earthnut 4 Xi acid is not OK according to Shu Shuian allpa重庆夜生活论坛ss, do not have a law to begin biology to ch东莞夜生活论坛ange below 长沙夜网论坛COX-2 catalysis reaction, PGs is generated receive b武汉夜网论坛lock, cut off inflammation whole process. The key that shows level to already developed a design is 2 annulus kind reach 3 annul西安夜网论坛us apperc长沙夜品茶网eption to close matter. 3 annulus apperception adds up to content key to include heterocyclic apperception to close matter, compound of product of annulus Xi series, compound of product of 3 benzene series. 2 annulus apperception adds up to content key to include former time benzene of fluorine of sulfur of compound of health series product, aniline compound, benzene and sulphur acid ester kind, butyl of 2 father’s younger brother replaces phenol kind etc. Show level to get together in the COX-2 delay of Chinese put on sale in the agent, 3 annulus apperception adds up to content a place of strategic importance to come former times cloth is FDA the first when allow also is exclusive a COX-2 is optional choose sex delay gets together agent, construction of benzene of fluorine of its benzene sulfur has taller optional choose sex to COX-2 albumen kinase, and do not have to COX-1 restrain the effect. And connect bad kind Ni Meishu benefit, beautiful Luo Xikang it is certain to have to COX-1 restrain the effect.
Delay of COX2 of optional choose sex gets together agent 3, China already delay of COX-2 of sex of a few kinds of of put on sale optional choose gets together agent
1, Ni Meishu benefit (Nimesulide)
Benefit of Buddhist nun beautiful stretch is most first the delay of COX-2 of optional choose sex of put on sale gets together agent, this medicine to be taken orally is digested absorb fast and complete, 1-2h amounts to chroma of bigger blood drug, t1/2 is 3h, classics liver is metabolic, kidney metabolizes, have antifebrile, acetanilide reach combat infection effect. IC50(COX-2)/IC50(COX-1) is 0.1, its check to the optional choose sex of COX-2 the optional choose sex of COX-1 is 20 times stronger.